Biology 3593B Lecture Notes - Lecture 4: Prodrug, Biotransformation, Enterocyte

• School: Western University
• Department: Biology
• Course: Biology 3593B
• Professor: Vojislava Grbric

Document Summary

Module (lecture) notes: conjugates include glucuronic acid (a sugar), sulfate (-so4), acetyl groups, or amino acids (i. e. glycine, metabolites are less active than the parent drug after phase ii metabolism, ex. Cyp3a4): following the prefix cyp, the first number represents the family, the next letter represents the subfamily, and the final number represents the specific isozyme, cyp3a4: metabolizes the largest fraction (~ 50%) of all currently marketed drugs. Sulfotransferases (sults: sulfotransferases (sults): cytosolic phase ii drug metabolizing enzymes, sults catalyze the transfer of a sulfate group to a drug, sulfated drugs are more polar and therefore more easily excreted, there are 11 human sult enzymes. Drug metabolism and enzyme induction smoking: non-smoker: some fraction of the drug is metabolized (converted to metabolite) by the liver, smoker: a much larger fraction of the drug is metabolized by the liver, due to enzyme induction.