Biology 1001A Lecture Notes - Lecture 16: Dna Mismatch Repair, Dna Repair, Semiconservative Replication
22 Oct 2016
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List of mechanisms to ensure inheritance of (cid:498)sameness(cid:499: semi-conservative replication, repair mechanisms, dna proofreading, cell cycle checkpoints, cytoskeleton, complementary base pairing, idea of telomerase, repair mechanisms. Sometimes proofreading fails and a mismatch persists behind a fork; that mismatch distorts the helix in ways that are detectable. 3" oh is the mechanism that allows proofreading. Replaced my polymerase, sealed by ligase mismatch repair/ excision repair that are side by side on the same backbone this is not a mutation. Anything that is not a double-stranded change in the mutation is called (cid:498)damaged(cid:499) So dimers are just (cid:498)damaged(cid:499) damage is repaired using enzyme called photolyase. Dimers can be repaired by photolyase or excision. Photons of uv have just the right amount of energy that they are trapped by thymine, destabilize electron clouds in ring, new covalent bonds between thymine. Our definition of mutation is that it is a double-stranded change in the dna sequence.
