Biology 1001A Lecture 2: Evolution in Viruses- Lecture 2.doc
Document Summary
Evolution in viruses/diseases in action- human immunodeficiency virus. Reasons why hiv is more common in some parts of the world than others. Factors that explain why no cure or universal vaccine has been developed for hiv/aids. Reasons why anti-viral drug therapies often have serious side effects. Specific role of integrase and reverse transcriptase in retroviral life cycle. Reasons why effectiveness of azt decreases over time. Rationale for multi-drug (drug cocktail) approach to treating viral infections. Principles of evolution of hiv: variation, heritability, differential reproduction, change in genotype of population. Role of ccr5- 32 mutation in human resistance to hiv infection. Likely explanations of modern distribution of ccr5- 32 allele. Kill up to 100 million people within next 50 years. Severe flu pandemic (very likely)-> 36, 000 in usa die every year of seasonal flu. New/better vaccines could end suffering since beginning of time. Power is so great (no longer polio, smallpox) After awhile you can barely hear them.