Biology 3316A/B Lecture Notes - Lecture 5: Pampers, Apoptosis, Malaria
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13 Jul 2019
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Rtk with breast cancer: there"s a variety of breast cancers, breast cancer can either be caused by a ligand or by the receptor. This was a way to take some of these techniques and make them better. One of the groups has added this compound in baby pampers, it expands it, and then they can use their microscopes to follow the expression of whatever protein you"re interested in or just normal development. One of the things is the thing that"s changed is glutamic acid. All it takes is one amino acid. If you type in her2, you often see /neu. It is not a broad scale change or not a loss of particular motif or cassette within a protein: from valine to glutamic acid and all you have activation of the pathway, you don"t even need a ligand. If this was discovered in rodents, it would be the her2 protein equivalent.
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