Biology 3316A/B Lecture Notes - Lecture 11: Rho-Associated Protein Kinase, Wnt3, Catenin
13 Jul 2019
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At least 19 wnts in humans and 10 frizzled: signaling crosstalk, planar cell polarity, wnt pcp signaling, rho/rac. Rho/rac are out of place in that this is a cancer cell line: jnk"s many faces. Jnk links planar cell polarity and links programmed cell death: autophagy. Schematic diagram of the potential cross talk between canonical and noncanonical pathways as mediated by wnt11 in hcc cells. Activation of the canonical wnt signaling induces cell proliferation and migration through -catenin stabilization and translocation to the nucleus, where it activates wnt-responsive target genes (dotted arrows). Catenin phosphorylation and results in inhibition of cell proliferation. Black arrows, wnt11- mediated activation of rhoa/rock inhibits rac1 activity and leads to inhibition of cell migration and motility. Both wnt3 (4) and wnt11 may be involved in tumorigenesis by reciprocal mechanisms. Thus, overexpression of wnt3 or downregulation of wnt11 or both may activate canonical -catenin signaling and contribute to a highly motile, invasive, and proliferative hcc phenotype.
