Biology 3355A/B Lecture Notes - Lecture 11: Phagocytosis, Dendritic Cell, Complement Factor B

• School: Western University
• Department: Biology
• Course: Biology 3355A/B
• Professor: Alexander Timoshenko

Document Summary

Nuclear factor kappa b (nf- b) is a transcriptional driver of immune and inflammatory responses, in addition to its roles in normal cell growth and development. This unit covers the inflammatory stress response concept focusing on the cell biological aspects of inflammation, toll-like receptors, and nf- b signaling pathways. Inflammation is a localized response to injury or infection that leads to the activation of immune-system cells and their recruitment to the affected sites. Inflammation is associated with the release of pro-inflammatory factors from immune cells. If it is not properly controlled, inflammation can lead to tissue damage and loss of function. Lawrence et al (2002) nat rev immunol 2(10):787-795. Inflammation is associated with the release of pro-inflammatory factors from immune cells such as cytokines, chemotactic and vasoactive molecules, pyrogenes and more, which contribute to the key signs of inflammation. The classical signs of inflammation are heat, redness, swelling, and pain.