Chemistry 3393A/B Lecture Notes - Lecture 17: Bioassay, Vardenafil, Angina Pectoris

• School: Western University
• Department: Chemistry
• Course: Chemistry 3393A/B
• Professor: Felix Lee

Document Summary

This topic is not covered in the textbook. Read referenced articles if interested (only material discussed in class will be examinable) British patent in 1991, us patent (5426107) filed in 1993. Viagra (i. e. sildenafil) is the best example of a drug that was discovered accidentally. Pfizer to treat angina the structure of this drug was associated with anti-anginal effects. So this drug was patented as its core structure so the r-groups can be anything, and it would still be. I(cid:374) a pate(cid:374)t, the(cid:396)e is a list at the end that shows all the issues this drug can treat. Pde-5 specifically hydrolyzes cgmp at the phosphodiester bond. Sildenafil was derived from the core structure of pyrazolopyrimidinones. So sildenafil was used in clinical trials to treat angina. It turns out that men at the age of 50-55 (the target group for angina), experienced the side effect of having more erections.