Chemistry 3393A/B Lecture Notes - Lecture 12: Combinatorial Chemistry, Lead Compound, Gaba Receptor

• School: Western University
• Department: Chemistry
• Course: Chemistry 3393A/B
• Professor: Felix Lee

Document Summary

This topic covers the following sections of the textbook: After studying this chapter, you should be able to do the following textbook questions: Chapter 16: 1 3 (hint: think about the side chains of tyr and lys) And these multiple-choice questions on the textbook"s website (http://global. oup. com/uk/orc/chemistry/patrick5e/): chapter 16: 1, 9, 13 15. You can make a bunch of compounds and test them for activity. You can extract compounds from plants and test for activity; once a compound is identified, the chemical structure needs to be derived. Here we need a chemical process of finding a lead compound. Deliberately make a mixture of many compound, in one container. Then you do an assay using the contents of the container you are testing all the compounds in the mixture in one assay. Ex: making 25 dipeptides from five different amino acids. Note: ala-gly is not the same as gly-ala.