Geography 2152F/G Lecture Notes - Lecture 16: Glutamatergic, Titration, Valproate
9 Nov 2017
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About 15-20 total drugs in treatment of epilepsy (2-3 main ones: expected to know mechanism of these drugs. Characterised by recurrent seizures: seizure is an abnormal synchronization of electrical neuronal activity. Epileptic seizure is this synchronization being better. High amplitude synchronous activity across the brain in epileptics. Epilepsy is defined as having seizures at some frequency. Untreated seizure tend to lead to more seizures. Fairly prevalent (0. 5-1% of world pop have some for of epilepsy) Not treated very well or not at all in 3rd world countries. Does(cid:374)"t re(cid:448)ert to (cid:374)or(cid:373)al a(cid:374)d (cid:449)ill last your lifeti(cid:373)e. Sudden unexplained death from epilepsy (sudep: unexplained. Types: generalized: involve entire brain, partial or focal seizure: localized onset, usually in a region of one cerebral hemisphere. 40%-50% of epilepsy patients have complex partial seizure with or without secondary generalization. 70-85% of complex partial seizures originate iin temporal lobes, particularly in hippocampus and amygdala.
