Geography 2152F/G Lecture Notes - Lecture 3: Tight Junction, Distal Convoluted Tubule, Hydrophile
9 Nov 2017
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Pharmacology lecture 3: still on drug absorption and distribution. Left off at estimating bioavailability of an orally administered drug. Bioavailability is the amount of dose that reaches the systemic circulation. Estimate of bioavailability is about 20% because the auc oral is about 20% of the whole. Alendronate (fosamax: for osteoporosis, bioavailability (f) = 0. 6% Warfarin (coumadin: blood thinner, f about 100% Brand name (cid:448)s. ge(cid:374)e(cid:396)i(cid:272) d(cid:396)ugs (cid:862)comparative bioavailability(cid:863): read slides for more notes. Generic drugs more commonly used by people because they cost less and contain the same medicinal ingredients as the original brand name drug. If you want to make a generic version of a drug you must be approved by health canada. They make sure that your generic drug has to have a similar relative bioavailability to the brand name in respect to the extent and rate of absorption to get approved.
