Kinesiology 2230A/B Lecture 3: Lecture 3
11 Jan 2019
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Soccer: 90 minute games, 10% anaerobic, 80% is low intensity, average hr - 170 bpm. Cofactors and coenzymes: cofactor - a nonprotein component of an enzyme. Iron, magnesium, manganese, cobalt, copper, zinc, etc: coenzymes are organic, derived from vitamins, coenzymes make up a part of the active site, without the coenzyme the enzyme will not function. Flavin adenine dinucleotide (fad) oxidation or hydrogen transfer. If atp accumulates in the muscle, it downregulates the pathway to stop producing atp. If adp accumulates in the muscle, it upregulates the pathway to produce more atp. Feed forward control - when something causes an accumulation of a substance and causes it to upregulate an enzyme later in the pathway. Rate-limiting, marker, or regulatory enzymes: the enzyme in a metabolic pathway where ultimate control (slowest reaction) is exerted, anaerobic (glycolysis) - pfk (phosphofructokinase, aerobic (kreb"s cycle) - cs (citrate synthase) and isocitrate dehydrogenase. Lactate threshold - activity that results in an accumulation of lactate.
