Kinesiology 3339A/B Lecture Notes - Lecture 16: Cardiac Arrhythmia, Saturated Fat, Mitochondrial Matrix
19 Oct 2016
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Document Summary
Arachidonic acid (aa) has adverse health affects: omega-3 fatty acids. Converted in body to epa and dha but slowly - need a lot in body. Docosahexaenoic acid (dha: structural differences between omega-3 vs. omega-6 fatty acids minor but the physiological great. Structure of linoleic acid (omega-6) vs. alpha linoleic acid (omega-3: linoleic acid. Omega 6 because double bond at 6th and 9th carbon from methyl group. But when looking from carboxyl group, double bonds at 9th and 12th carbon: alpha linoleic acid. The only structural difference is that this acid has a double bond at 3rd, 6th and 9th carbon from methyl group. But when looking from carboxyl group, double bonds at 9th, 12th and 15th carbon. Thromboxanes: involved in blood clotting and vasodilation/vasoconstriction. Prostaglandins: involved in vasodilation/vasoconstriction and blood clotting. Leukotrienes: involved in allergic response and inflammation: omega-6 eicosanoids. Are prothrombotic, proaggregatory, proinflammatory = increase blood viscosity and vasoconstriction: omega-3 eicosanoids.
