Kinesiology 4430F/G Lecture Notes - Lecture 4: Insulin-Like Growth Factor 1, P38 Mitogen-Activated Protein Kinases, Glycogen
20 Dec 2017
School
Department
Course
Professor
Document Summary
Animal study: evidence that mtor pathway is not the cause of hypertrophy, measured the activity of the if2b after some resistance exercise in hind limb muscles. Sedentary: moderate diabetic significant increase in if2b activity, slightly low in insulin and still got the same effect, non-diabetic - significant increase in if2b activity. Effect of eaa or eaa + exercise on muscle p70s6 kinase activity. Human study: observing p70s6 activity during quad extension exercise, there is an increase in activity with aa, and a synergistic increase with. Aa + exercise: both are upregulated after anabolic conditions to increase protein synthesis, happens quickly because cell is reading the messenger. 3 ways in which you can breakdown muscle protein: In response to high ca+ levels, disassemble the sarcomere proteins: z-band disintegration - takes away actin + myosin from z-lines and allows them to be degraded, also upregulated in disease (ex. cancer that causes muscle atrophy)
