Microbiology and Immunology 2500A/B Lecture Notes - Lecture 36: Tumor Suppressor Gene, Copy-Number Variation, Basal Lamina
10 Jan 2017
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Started with ted talk - harvard med school cancer drug jq1 https://www. ted. com/talks/jay_bradner_open_source_cancer_research. Cancer cell forgets it is a cancer cell, grows arms, and acts like a normal cell. Completed clinical trials in mice - the ones that get the treatment live and the ones that do no perish. After 40, cancer is much more prevalent. Usually, more than none mutation is responsible for cancer. A single mutation is not suf cient to cause cancer. Tumour progression involves successive rounds of mutation and selection. At each round, the descendent acquires another mutation allow it to grow faster or in abnormal places. Most cancers derive from a single abnormal cell: First mutation allows a cell to grow more quickly. Second mutation may allow the cells to grow in the absence of the basal lamina. A third mutation may allow the cells to penetrate the basal lamina. Multiple mutations are needed, it takes time to acquire those therefore cancer risk increases with age.
