Microbiology and Immunology 2500A/B Lecture Notes - Lecture 28: Protein A, Lysis, Vancomycin
16 Jan 2017
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Document Summary
Secreted virulence factors (exotoxins) expressed during stationary phase. Generally, surface virulence factors are for colonization purposes, while secreted virulence factors are for invasion and spread. Antibodies are bound in the incorrect orientation to be recognized by. S. aureus can make a number of cytolytic toxins that kill white blood cells. Often called (cid:498)hemolysins(cid:499) because they can lyse red blood cells. Actual targets are mostly white blood cells. Helps to protect s. aureus in abscesses and for spreading. First formally described as a systemic illness in 7 children associated with non- invasive staphylococcus aureus infection. Characterized by acute onset of fever, hypotension, rash, multi-organ dysfunction, (desquamation) Caused by both staphylococcus aureus and streptococcus pyogenes. Staphylococcal tss has menstrual and non-menstrual forms (<5% mortality) Streptococcal tss occurs in association with invasive streptococcal disease ((cid:498)flesh- Function to over activate large numbers of t cells and cause a systemic eating disease) (>40$ mortality) inflammatory response.
