Microbiology and Immunology 2500A/B Lecture 20: Lecture 7_ HIV Pathogenesis
4 Apr 2020
School
Department
Professor
Document Summary
Hiv is one of the most successful viruses at killing individuals. Pts : young men with a new form of cancer (kaposi sarcoma) Lung infection causing pneumocystis pneumonia back and mouth around neck , (caused by fungus) Grid ( gay - related transmission can since. 12 see death every infection every people with aids deaths from aids globally globally infections in sub - saharan africa ( up to 394 infection rates) Cart ( combined antiretroviral therapy) is a drug cocktail used globally. Late : transcription integration into host genome of proverbs genes and onward. Viral proteins often are capsid identified by molecular weight. Surface protein japanese"s gp 120 : viral receptor gp will and host receptors. Hiv entry gp 140 binds cd4 gp 140 can now bind ccr51c cr4 (co receptor) gp4l. Proximity of membranes results in fusion inserts into pm. Lacks 3" -75 " exonuclease activity (proofreading) l - 10 errors per synthesis.
