Microbiology and Immunology 2500A/B Lecture Notes - Lecture 8: Rh Blood Group System, Epitope, Blood Transfusion
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18 Jun 2016
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* b-cell receptor has 2 chains (blue is heavy chain, red is light chain) * if you took the b cell receptor and folded it in half, the 2 sides are identical. * it"s bound to the surface of the b cell to the transmembrane region. * t cell receptor has 2 chains, alpha and beta chain, both bound to surface of transmembrane region. * if we further look at the struc, the end segments of the b cell receptor makes up the variable regions; same with t cell receptor. * so at b cell receptor, there are 2 identical variable regions; this will bind the antigen. E. g. h1n1 virus has 2 antigens expressed: hemagglutinin and neuraminidase; virus is covered by these antigens. * among antigens, there are many diff shapes on the surface, which are epitopes; variable regions bind to epitopes. * binding is simply based on whether they fit structurally.
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