Microbiology and Immunology 3820A Lecture Notes - Lecture 7: Staphylococcus, Toxic Shock Syndrome, Staphylococcus Saprophyticus
9 Dec 2016
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Inhabits anterior nares, skin, and throat: cell wall virulence factors. Protein a which binds to the fc portion of igg and inhibits phagocytosis. Fibronectin-binding protein (fnbp: membrane damaging exotoxins: A, b, y, o, and leucocidin: superantigen exotoxins. These protein toxins have an affinity for a relatively high conserved region of the t cell receptor, the mhc class ii complex. They stimulate a massive t-cell response (~20% contrasted with the usual 0. 01%) with outpouring of t-cell cytokines tnf-a, il-2, and interferon y. Exfoliatin which causes the expanded staphylococcal scalded skin sindroms. Enterotoxins a,b,c,d,e,g which cause staphylococcal food poisoning. 4 major staphylococcus aureus diseases: 1. Skin and soft tissue i and d is mainstay of therapy, bone osteomyelitis: 2. Food poisoning: enterotoxins a-e and g. Expanded staphylococcal scalded skin syndrome: ritters disease, classic scalded skin syndrome, staphylococcal scarlet fever, bullous impetigo. Toxic shock syndrome: high fever, hypotension.
