Medical Sciences 3999A/B/Y Lecture Notes - Lecture 30: Sickle-Cell Disease, Blood Film, Epb41
2 Mar 2020
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Specialized connective tissue consisting of cells (formed elements) and plasma (protein-rich fluid). Transport nutrients and o2 directly or indirectly to cells. Transport of wastes and co2 away from cells. Delivery of hormones and other regulatory substances to and from cells and tissues. Maintenance of homeostasis by acting as buffer and by participating in coagulation and thermoregulation. Transport of humoral agents and cell immune system (protection against pathogenic agents, foreign proteins and transformed/cancer cells) Low hematocrit reflect anemia or significant blood loss (internal/external bleeding) *leukocytes and platelets together make up 1% of blood volume. Plasma: liquid ecm that imparts fluid properties to blood. Relative volume of cells and plasma in whole blood = ~45-55% *components separated by centrifugation, if blood is collected in the presence of anticoagulants. Glycophorin c: attach cytoskeleton network to cell membrane. Band 3: exchange cl- for hco3- across plasma membrane, and binds cytoskeletal proteins.
