Pathology 3240A Lecture : Class 11.docx
3 Mar 2014
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Document Summary
Biology of tumor growth transformation (normal to tumour cell: most human tumour are derived from single transformed cell (monoclonal orgin, transformed cells, autonomous self sufficiency in growth signal and resistance to growth inhibitory signals, resistance to apoptosis, defective dna repair, unrestricted proliferation growth of tumour cells, angiogenesis, tumour progression and heterogeneity, bring blood vessels, tumour growth doubling time. Angiogenic factors: produced by tumour cells, produced by inflammatory cells infiltrating tumour, chemotactic and mitogenic for endothelial cells, ex, fibroblast growth factor (fgf, vascular endothelial growth factor (vegf, produced by tumour cells, but named after cells that, tumour progression and heterogeneity they were discovered in. Over a period of time, the tumour may acquire various subpopulation of cells: subpopulation may vary, antigenicity, invasiveness, metastatic potential, growth factor requirement, heterogeneous tumour when discovered local invasion, the phases of metastasis invasion of extracellular matrix basement membrane, collagen, etc.
