Pathology 3500 Lecture Notes - Lecture 7: Type Iv Collagen, Scurvy, Cell Adhesion
21 Mar 2018
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Document Summary
Restoring tissue: remove dead tissue, removal exudate, removal of cellular and tissue debris, replacement of cells and tissues lost. Liver , lung: permanent= no reactivation possible, replaced by connective tissue, heart attacks and stroke, heart and neural cells cannot be replaced, all cells in our blood can regenerate. Regeneration: physiological: function and structure restored, atypical: cells functional but structure not fully restores, the cells are repaired but functionality has not be restored - atypical process. In the liver, cell regeneration of the liver cells. Mechanisms involved in regeneration and repair: control of cell proliferation, recruitment of g0 cells into the cell cycle this takes place by the action of, growth or stimulatory factors, cell-cell or cell-matrix interactios. Loss of a growth inhibitor normally present (negative feedback: cells growing next to each other but stop growing when the touch each other, need a loss of this function. In ecm are glue like protein and glucan like substance.
