Pharmacology 2060A/B Lecture Notes - Lecture 5: Hydrostatics, Arteriole, Amphiphile
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4 Jan 2021
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Drug excretion is the removal of parent drug and drug metabolites from the body. Sites of drug excretion kidney, bile, lung, breast milk. Renal drug excretion the kidneys account for the majority of drug excretion. Healthy kidneys serve to limit the duration and intensity of drug effects. Decreased kidney function prolongs the duration of action and intensity of drug effects. The nephron basic structural and functional unit of the kidney. Controls blood volume, blood pressure, blood ph and solute (including drug) excretion. 5. 2 factors affecting renal drug excretion: glomerular filtration. Drugs enter the kidney from the renal artery. Hydrostatic pressure within glomerular capillaries forces low molecular weight drugs into the renal tubules. Glomerular filtration rate is about 120 ml/min/1. 73m 2 or about 20% of total renal plasma flow. Lipid solubility and ph do not affect glomerular filtration of drugs. Only non protein bound (free) drugs are filtered at the glomerulus: tubular secretion.
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