Pharmacology 3620 Lecture Notes - Lecture 10: Enteric Coating, Drug Injection, Portal Venous System
12 Oct 2016
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*enteral = anything given within intestinal tract; parenteral = anything given outside of intestinal tract (in this case refers specifically to injectable routes) Describe what happens after a drug is administered orally. Drug absorption in the stomach is minimal. This is because the surface area of the stomach is relatively small and the lining of the stomach is covered by a mucous layer. The majority of drug absorption occurs in the small intestine due to large surface are created by millions of villi. Drug absorbed from the intestine is carried by the portal circulation to the liver, the primary site of drug metabolism: this is why some orally administered drugs undergo a large degree of first pass metabolism. Describe why some drugs must be administered with food and others must be taken on an empty stomach. Food can delay the absorption of some drugs. Some drugs are irritating to the stomach.
