Psychology 2070A/B Lecture Notes - Lecture 3: Disulfide, Alpha Helix, Beta Sheet
16 Sep 2012
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Given: pka of -amino group = 10. 0 pka of -carboxyl group = 2. 0. *we will work this out in class together. Therefore, a charge on a alpha-amino group is +1(1)=1. Therefore, charge net charge on amino acid is (+1) + (-1)=0. Hydrogen bonds occur between the backbone of two or more polypeptide chains arranged adjacently and in parallel. Side chains project alternately up and down. Anti-parallel form (c-terminus lined up with n-terminus, n with c ) Parallel beta pleated sheet c-terminus lined up with c, n lines up with n. Hydrogen bonding between these makes the folds in the beta sheet. Silk fibroin (extremely strong material) consists mostly of -sheets. Most proteins have both -helices and -sheets, plus turns and other less regular structure. Primary sequence determines type of structure formed. Concerns the 3d arrangement of the polypeptode chain. Stabilized by bonds between side chains or side chains to.
