Rehabilitation Sciences 3062A/B Lecture 10: Lecture 10
12 May 2017
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Document Summary
Group of diseases with different underlying disease pathology: all affect the basal ganglia. Parkinson"s disease (pd) is the most common form of parkinsonism: other diseases are: Multiple system atrophy (msa) or shy-drager syndrome. Average age at diagnosis = 60 years. Direct costs associated with pd = . 8m. Dependence in adls happens 3-5 years after diagnosis. From substantia nigra compacta: 80% of brain"s dopamine in bg. Binds with 2 types of receptors: d1 = facilitates activity in direct pathway, d2 = inhibits activity in indirect pathway. Degeneration of dopaminergic neurons in snc . Increase activity indirect pathway & decrease activity direct pathway . Lewy bodies: aggregation of (alpha) a synuclein, start in brain stem and ascend to cortex. Postural instability gait and balance problems: gait: Can be present in the extremities, lip, jaw or tongue: not present in head, pill-rolling in hand. Presenting symptom in ~ 70% of people diagnosed with pd.
