Rehabilitation Sciences 3062A/B Lecture 3: Grey and White Matter

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Grey matter: areas made up mainly of neuron cell bodies, usually 2-4mm thick. Surface of cerebral hemispheres covered by layer of grey matter: cerebral cortex, grey matter also found in large clusters called nuclei located deep within the cerebral hemispheres and brainstem, basal ganglia, thalamus. White matter: myelinated axons, pathways, 3 categories, projection fibres, commissural fibres, association fibres. Commissural fibres: connects like areas between left and right hemispheres. Largest commissure: corpus callosum, anterior and posterior commissure link the temporal lobes. Association fibres: connect cortical regions within the same hemisphere. Long association fibres: connect lobes within the same hemisphere. Cns: grey and white matter: cerebral hemispheres, grey - outside, white - inside. Spinal cord: grey - inside, white - outside, brainstem, grey and white found both inside and outside, most of outside is white matter. Loss of myelination through pathology: multiple sclerosis in cns, guillain-barre in pns.

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