KP322 Lecture Notes - Lecture 22: Peripheral Chemoreceptors, Central Chemoreceptors, Carotid Body
19 Mar 2020
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At sea level changes in po2 have a small effect on ve. Environmental changes can decrease po2 and stimulate peripheral chemoreceptors. Carotid bodies monitor arterial blood as it perfuses the brain. Anticipation of exercise stimulate respiratory neutrons in the medulla to imitate the abrupt increase in exercise ventilation. Sensory input for joints, tendons, and muscles in uence ventilatory adjustments during exercise. Increase in blood h ions stimulates carotid bodies. Also increase in k+, body temp, and blood catecholamdides. Combines simultaneous effects of several cehemical and neural stimulus initiate modulate exercise alveolar ventilation. Pheses of ve in exercise and recover. Phase 1 = imitation and abridge increase. Phase 3 = nd tuning and levelling off. No effect on lung structure and function at rest. Normal lung exceeds demand for gas exchange. Adaptations not required for lung to maintain blood-gas homeostasis. Pulmonary system not seen as a limitation. Historically not thought to be a limitation in healthy individuals at sea level.
