BIOL 1000 Lecture Notes - Lecture 16: Succinyl-Coa, Acetyl-Coa, Pyruvate Dehydrogenase

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Lecture 16, pyruvate oxidation & krebs cycle in the investment stage you give glucose 2 atp. What you get out of it is 4 atp, 2 pyruvate & 2 nadh: in glycolysis you don"t lose any carbons, there is however a change in potential energy. Pyruvate oxidation (takes place inside the matrix: 2 pyruvate turn into acetyl - coa, 2 nadh are produced (1 for each pyruvate molecule, 2 co2 are released (1 for each pyruvate molecule) It is a complex because there are 3 proteins coming together. Decarboxilation: means that you are removing a carboxyl group, which is why we can go from 3-carbon pyruvate to 2-carbon acetyl-coa and release co2. There are 8 major catalyzed reactions in the krebs cycle. Citric acid cycle always begins with oxaloacetate (4 carbon molecule). Acetyl-coa interacts with oxaloacetate, giving you a 6 carbon molecule (citrate). An isomerase enzyme will change citrate into isocitrate. The rst nadh & co2 are created when.

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