BIOL 1001 Lecture Notes - Lecture 10: Zygosity, Malaria, Hemoglobin

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29 Jan 2018
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Evolution: a change in the allele and/or genotype frequencies of a population. If not in h-w eqm, then population is evolving. Causes of evolution: natural selection, genetic drift, gene flow, non-random mating and mutation. If any of the following are not occurring, only then will the h-w equation work. Assumption #1; all individuals in a population are equally likely to reproduce. Alleles combine at random to form new genotypes. Natural selection eliminates phenotypes that are unfit for a given environment; changes allele and genotype frequencies, causing evolution. Selection against a recessive trait does not eliminate recessive alleles. Rate of elimination decreases as q decreases. Because natural selection works directly against unfit traits, the rate of elimination of a recessive allele is a function of q^2. Heterozygote advantage: when fitness of heterozygote is greater than that of either homozygote. Can maintain high frequency of a recessive allele that is harmful in homozygote.

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