BIOL 2021 Lecture Notes - Lecture 7: Oligosaccharide, Flippase, One Direction
12 May 2013
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Document Summary
Protein + stop transfer sequence + signal mitochondria. Same as inner membrane space + protein cleavage. Chloroplasts fig 12. 21: 3 compartments, 3 membranes, specific membrane for each. Thylakoid figure 12. 29: similar to mitochondria. Chloroplast signal seq thylakoid seq thylakoid precursor. Inner lumen is continuous: reticulum = network. Rough er ribosomes for protein synthesis. Function of er: synthesis of proteins. Transmembrane, secreted, lumen of er, golgi, lysosomes, made in rough er: most lipid synthesis for organelles smooth er, ca2+ store signalling like muscle contraction. Sarcoplasmic reticulum: co translational import of proteins. Signal sequence made first start transfer sequence. Signal recognition particle (srp) binds to sequence. Binds to its own receptor (within the er membrane) Polyribosome many ribos on one mrna. Same pool of ribosomes for cytosolic and er proteins. Some proteins gain a gpi anchor: 9. Transfer protein to gpi (this will happen before release into er lumen) Release protein into lipid bilayer (membrane: 13.
