KINE 2011 Lecture Notes - Lecture 15: Pyruvic Acid, Ionophore, Citric Acid
24 Oct 2017
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Electron transport & chemiosmosis can be uncoupled: chemicals called ionophores from channels across membranes through which ions, including protons, freely pass. Ionophores allows protons to flow: when etc is not coupled w/chemiosmosis synthesis of atp, free energy released during etc is not conserved but released as heat. This mechanism is important ulating body temperature in animals. Atp yield & efficiency: total of 34 atp by oxidative phosphorylation + 2 atp from glycolysis & 2. Total =38 atp: 38 is theroretical yiel, its usually 36 atp, now 100% efficient, energy is used to actively transport molecule, inner membrane could be leaky, h+ protons will move back into matrix, efficiency is 38% Cellular respiration regulations: respiration is controlled so the atp produced matched cells requirement, the end-products of pathway inhibit an enzyme early in the pathway, e(cid:374)zy(cid:373)e i(cid:374) glycolysis that"s regulated is phosphofructoki(cid:374)ase. It is a(cid:374) allosteric enzyme whose acticity can be adjusted binding of activators or inhibitors.
