NATS 1670 Lecture Notes - Lecture 19: Anaphylaxis, Adverse Effect, Respiratory Tract
17 Mar 2017
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Document Summary
Mast cells settle in connective tissues and usually do not circulate in the blood stream. Play a central role in inflammatory reaction. Both mast cells and basohpils play a central role in immediate allergic reactions. Both contain granules filled with inflammatory chemicals such as histamine. They are able to release the potent inflammatory mediators. May be induced by aggregation of ige bound to high-afinity receptors (fc. Specific antigen (allergen) is responsible for the ige aggregation. The hypersensitiviy reactions are usually mild and localized. Site of reaction depends on the portal of entry. Inhaled allergens may cause hay fever, an upper respiratory tract response. Marked by watery nasal discharge, sneezing, itchy throat and excessive tear production. Commonly caused by mold spores, pollens, flowering plants, some trees, and dust mites. There is a strong genetic component to asthma. However it takes more than just genetics to have an attack. Induces bronchial smooth muscle to over-secrete mucus to contract.
