HUBS192 Lecture Notes - Lecture 26: Centroacinar Cell, Alpha-Amylase, Ph

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Ivan pavlov: russian physiologist: famous for his work on condition reflex (training on dogs and gi secretion; contribution that pavlov gave to our understanding of secretions) Components of exocrine secretion: enzymes carry out chemical digestion, mucus: provides protection/lubrication, electrolyte (ions) solution: diff ions being secreted into the lumen and can set up diff. ph ; optimising function of the enzymes. 3 pairs of salivary glands; each contributes diff. components of saliva. Buccal glands in oral mucosa and cheeks also secrete salivary-like material to maintain oral mucosa; not as important as secreting saliva into the mouth than the salivary glands. All 3 pairs use the same mechanism for producing saliva: secretion from acinar cells; secretion modified as they move along the duct (2 stage model for producing saliva) 1st stage: primary secretion: secretion from acinar cell in the ends of the glands; produce isotonic secretion (same osmolarity as plasma); serous solution (protein also secreted from acinar cells)

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