BIOL 2011L Lecture Notes - Lecture 4: Blood Sugar, Extracellular Fluid, Fluid Balance

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Each of these variables is controlled by one or more regulators or homeostatic mechanisms, which together maintain life. Homeostasis is brought about by a natural resistance to change in the optimal conditions,and equilibrium is maintained by many regulatory mechanisms. All homeostatic control mechanisms have at least three interdependent components for the variable being regulated: a receptor, a control centre, and an effector. The receptor is the sensing component that monitors and responds to changes in the environment, either external or internal. Control centres include the respiratory centre, and the renin-angiotensin system. An effector is the target acted on, to bring about the change back to the normal state. At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up- regulation or down-regulation, and act in negative feedback mechanisms. An example of this is in the control of bile acids in the liver. Some centres such as the renin-angiotensin system, control more than one variable.

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