PSYC3338 Lecture Notes - Lecture 5: Tricyclic Antidepressant, Hypothyroidism, Amyloid Beta
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An oligomer = a molecular complex that consists of a few monomer units, in contrast to a polymer, where the number of monomers is not limited. Thought to be more damaging than plaques. Check out the url in slide #2, as it explains this in much more detail! Has levels of complexity, psychological cellular molecular levels of understanding, etc. Ab levels are correlated with synaptic loss and clinical severity in ad. Long term potentiation (ltp) strengthens synapses thus improves memory! 2 kinds of glutamate receptors, ampa and nmda. Nmda activation helps keep ampa open longer and yields new ampa receptors to further increase synaptic efficacy. Glutamate is an amino acid that works as an excitatory nt (always) Check the url on this slide to go over the mechanisms for the exam! Increased ab (beta amyloid) reduces synapse number and synaptic efficacy (ltp) Ab facilitates absorption of nmda receptors into the cell by endocytosis (by phosphorylating it).
