BIOL-242 Lecture Notes - Lecture 24: Macrophage, Cd86, Dendritic Cell

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Chapter 21 part 5| activation of t cells. Antigen encounter activation // when a lymphocyte"s antigen receptors bind to its antigen, that lymphocyte can be activated. Proliferation and differentiation // activated lymphocytes proliferate multiply) and then differentiate into effector cells and memory cells. Memory cells and effector t cells circulate continuously in the blood and lymph and throughout the secondary lymphoid organs. Genes, not antigens, determine which foreign substances immune system will recognize. Immune cell receptors result of acquired knowledge of microbes likely in environment. Lymphocytes make up to billion different types of antigen receptors. Gene segments are shuffled by somatic recombination. Present fragments of antigens to t cells for recognition. Dendritic cells in connective tissues and epidermis. Macrophages in connective tissues and lymphoid organs. Antigen presenting cells cleave the antigen and expose a portion of it on their surface, associate with an mhc class i or ii molecule.

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