MCELLBI 104 Lecture Notes - Lecture 20: Jargon, Lac Operon, Conserved Sequence
8 Apr 2016
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Can systematically answer that question by making cdna libraries, sequencing the ends of those, picking the largest cdna to sequence the inside of, see how you can learn things like how brain. Slide 10-11: disease snps frequently positioned within enhancer elements, hedgehog gene (shh), control so much of human development and disease; also involved in limb patterning; limb defects, extra digest, messed up positioning, point mutation in long-range enhancer. Slide 12: cancer, prostate cancer risk, myc gene (self-proliferation gene, myc, oncogene, etc, enhancer important. Protein localization important for cell biology part of the course; how proteins localize, etc. Slide 16: genetic mutation, segregated, overall flies normal but no eyes, transcription factor encoded, close relative in mammals, called. They bind really strongly to the epitope it"s evolved to bind! Which one have the protein product of interest: don"t study jargon, just know you can study when/where proteins are made in tissue.
