MCELLBI 104 Lecture Notes - Lecture 35: Antigen, Insulin, Vasodilation
8 Apr 2016
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Miller"s final exam: cumulative, can be asked anything from previous time to now. Today"s lecture: two kinds of signal transduction, how receptor ligands interactions happen on cell surface, one specific example of this receptor-ligand interactions called. Many responses: shift in metabolism, choice whether to grow mass, proliferate, whether to die, saw migration, can decide to differentiate, etc, huge number of signals and transduction pathways. Slide 4: there are long lists of cellular signaling molecules that we can come up with, we"ll talk mainly about 2 pathways this week, gpcr pathway: adrenaline. Hormone, long-range diffusible signal: egf receptor. Slide 6: most receptors are endocrine-type, you have a signal released at quite a distance from its target, signal carried through intracellular space, in our bodies, most are carried through blood by blood vessels, targeting distant target cells. Inverse: antibodies bind to antigen in much higher affinity, so dissociation constant is going to be smaller than insulin"s.
