MCELLBI 32 Lecture Notes - Lecture 14: Myasthenia Gravis, Myosin Head, Nicotinic Acetylcholine Receptor
20 Nov 2018
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Mcb lecture #14-skeletal muscle: which of the following does not have nachr receptors, effector organs for the parasympathetic nervous system, motor neurons are efferent and control skeletal muscle contraction. What would be the best treatment, especially in the early stages of the disease: acetylcholine esterase inhibitor. In order to do this, binds calcium: during a muscle contraction, the sarcomere gets shorter. Crossbridge cycle (myosin/actin when they"re bound together: 1. Binding of myosin to actin, inorganic phosphate is released. Power stroke, actin gets pulled toward muddle of sarcomere: 3. Rigor (myosin in low-energy form), adp is released: 4. Unbinding of myosin and actin, atp is hydrolyzed, new atp binds to myosin head, needs atp to unbind: 5. Myosin hydrolyzes atp, head moves back, cocking of the myosin head (myosin in high-energy form) What is rigor mortis: couple of hours after death. characterized by very stiff limbs and lasts for several hours before the body goes limp.
