NUSCTX 10 Lecture Notes - Lecture 23: Sex Steroid, Carcinogen, Calorie Restriction
2 Dec 2016
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A baby quadruples in size in a year. Sex steroids increase growth rate but lead to closure of bone epiphyseal growth plates = end of bone length and body height gain. Growth takes up a lot of energy. Adolescence can even call for 3k-4k kcal. Unique mutations of cells to be autonomous and out of control. Growth advantage and clonal expansion of cells with initial mutations. Prevention so much more effective than treatment. Slow cell division and prevent genetic damage. Generate free radicals and cause genetic damage. Increase cell division by providing growth stimulus. Prostate, colon, and breast cancer the most common cancers. Anything that increases proliferation rate of epithelial cells can be a tumor promoter. Carcinogen can be part of normal body. Later you have your first full term pregnancy, more likely to get breast cancer. Can cause cells to die before they become cancerous. Reduce meats to rda and don"t overcook.
