CAS PS 231 Lecture Notes - Lecture 3: Transcranial Magnetic Stimulation, Hemoglobin, Positron Emission Tomography
3 Oct 2016
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Document Summary
Destroys only cell bodies, spares axons passing through the region. Limitations human lesions not specific, animal brains not all same, damage to surrounding areas during surgery. Staining: allows fine details of the brain to become visible so you can locate lesion. Perfuse brain, fix brain, slice brain, stain brain location of lesion. Anterograde tracing: labels the axons and terminal buttons leaving a particular region. Retrograde tracing: labels cell bodies that give rise to the terminal buttons that form a synapse with cells in a particular region. Computerized axial tomography (ct/cat scan): uses x-rays, help detect tumors/abnormalities. Magnetic resonance imagining (mri scanner): find location of lesion in living human brain; measures the magnetic spin of hydrogen ions. A magnetic field causes hydrogen atoms to align in the same orientation. A brief radio frequency wave causes them to tile. When the radio frequency wave passes through the head, atomic nuclei emit electromagnetic energy.
