1. Hexokinase I has two domains each with a site that can bind glucose-6-phosphate inhibitor with equal affinity. However, the enzyme can bind only one molecule of glucose-6-phosphate at a time. What does it tell us about the effect of glucose-6-phosphate on the enzyme?
2. Glucose-6-phosphate is a competitive inhibitor of hexokinase I in respect of ATP but
a non-competitive inhibitor in respect of glucose. What does it tell us about the binding and physiological function of glucose-6-phosphate?
3. (2%) Indicate which secondary structure or structures (α -helix, β -pleated, random coil) will the following peptide adopt in an aqueous solution at pH 7 Gly-Pro-Glu-Ser-Ala-Tyr-Lys-Thr-Leu-Phe-Asp-Val-Pro-Asp-Asp-Glu-Asp-Gly-Gly