SAR HS 396 Lecture Notes - Lecture 20: Model Selection, Acceptable Daily Intake, De Minimis
9 Aug 2018
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Document Summary
Qualitative uncertainties around low exposures in carcinogenicity in hi. Hypothetical concentrations and rates versus actual concentrations and rates for true shape of dose-response model and extrapolating from rats ho humans in dra specific populations of interest in the ea. When dealing with uncertainty factors divide by 10 (in powers of 10) Hierarchy (divide by 10 each step: animal data (noael) inadequate animal data, human extrapolation, human variability/individual sensitivity, reference doses or acceptable daily intake. Physiologically based toxicokinetic models (distribution and metabolism) increase sample size. Comparing risk and costs for different risk management strategies. De minimis risk: some risks are so small they are acceptable or insignificant from a societal perspective, value of 1 in 1 million threshold for excess cancer risk. Activities below this threshold are considered acceptable. Risk-benefit analysis and cost-benefit analysis: some risks from activities that are otherwise beneficial.
