SAR HS 396 Lecture Notes - Lecture 13: Exposure Science, Toxicokinetics, Statistical Power

• School: Boston University
• Department: Health Sciences
• Course: SAR HS 396
• Professor: Bria Dunham

Document Summary

Exposure science focuses on quantifying the contaminant exposures people experience as they go about their daily activities evaluating factors that influence these exposures, and exploring new and innovative measure methods designed to quantify exposure and effect. Exposure assessment: quantification of exposure in both environmental and occupational setting. Dose: magnitude, frequency, and duration in assessment. Exposure profile: the time course of exposure of an agent to determine how bit, how worker, and how long exposures will have on workers health. Dependant on toxicokinetics and toxicodynamics of an agent and how readily metabolized or cleared at low levels of exposure and how toxic and higher levels of exposure. Assesses peak concentration: highest magnitude, frequency and duration of exposure during the monitoring period takes into account acute, sub-chronic, and chronic: other assessment measures exposures. Exposure assessment primarily developed around inhalation exposures. 2 other ways to assess ingestion exposure.