BIOL 1260 Lecture 21: Pharmacology of Cancer
2 Dec 2016
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Document Summary
Uncontrolled growth and spread of abnormal cells. Neoplasm: new growth of tissues that serves no physiological function: tumor: clumping of neoplasmic cells. Metastasis: process by which malignant tumors that are not enclosed in a protective capsule spread to other organs. Prostate/breast, lung cancer most common (lung has highest % death) Pancreatic cancer is rare but very deadly pancreatic cancer. Exocrine tumors (ductal adenocarcinoma: metastasizes early, presents late, more aggressive than neuroendocrine tumors, survival rate 5% Neuroendocrine tumors: quite rare, can be benign or malignant, survival rate 50-80% Treatment: surgery: total/distal pancreatectomy, radiation therapy, chemotherapy, drugs incorporate into dna mutagens as a cause of cancer. Viruses: retroviruses, dna viruses cancer as a disorder of the cell cycle. Tumor suppressors (cell cycle brake pedal: transcription factors (p53, cell cycle regulators (rb) Proto-oncogenes (cell cycle gas pedal: receptor tyrosine kinases (egfr and vegfr, kinases (src, abl, cdks, gtpases (ras, transcription factors (myc) properties that characterize cancer cells.
