GEN-3000 Lecture Notes - Lecture 14: Reactive Oxygen Species, Wild Type, Neutral Mutation
7 Nov 2020
School
Department
Course
Professor
Document Summary
Chapter 14 - gene mutation, dna repair, and. D n a molecule stores, replicates, transmits, and decodes information: changes in d n a sequences give rise to variations. Result in phenotypic variability, adaptation to environmental changes, and evolution: mutations provide basis for genetic analysis. Gene mutations: base-pair sequences of d n a within surrounding individual genes. An alteration in nucleotide sequence in genome. Major alteration in chromosomal structure: mutations can occur in. Types of mutations: mutations: classified by molecular change another. Point mutation or base substitution: change from one base pair to. Missense mutation: results in new triplet code for different amino acid. Nonsense mutation: results in triplet code for stop codon (translation terminated prematurely). Silent mutation: new triplet code still codes for same amino acid. Transitions: pyrimidine replaces pyrimidine, or purine replaces purine. Result from insertions or deletions of nucleotide. Loss or addition of nucleotide causes shift in reading frame. Frame of triplet reading during translation is altered.
