BMS 460 Lecture Notes - Endocytosis, Bile Acid, Ferrous
26 Apr 2014
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Document Summary
Clinical signs and symptoms of multiple myeloma are a consequence of uncontrolled proliferation of neoplastic plasma cells. Plasma cell hypersecretion monoclonal protein amyloidosis, hyperviscosity, renal failure, bence jones proteinuria, electrophoresis. The gi tract is subdivided into several functional units by muscular sphincters that regulate the orderly passage of contents from one part of the tract to another. The mucosal layer is composed of specialized squamous or glandular epithelium that overlies the lamina propria (loose connective tissue and resident chronic inflammatory cells). Underlying the mucosa is a thin muscularis mucosa that separates it from the submucosa composed of adipose tissue, vessels, and nerves. All these structures are surrounded by a muscularis propria (externa) composed of two layers of smooth muscle. The gi tract has an intrinsic nervous system that controls peristalsis (rhythmic contractions that move food and fecal material through the gi tract) with both a submucosal and intermyenteric plexus of nerves and ganglia.
