BMS 460 Lecture Notes - Neutrophil, Glycoprotein, Seminoma
26 Apr 2014
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Document Summary
Tumor cells produce receptor proteins, enzymes, and autocrine factors to facilitate attachment to, degradation of basement membrane components and migration away from site of origin. Type iv collagenase damages type iv collagen degradation. Primary tumor metastatic clone evolves proliferation of the clone and invasion of vessel transport by circulation embolization invasion new tumor formation at the site of metastasis. Tumor-cell invasion and migration: diversity and escape mechanisms. Cancer cells possess a broad spectrum of migration and invasion mechanisms. These include both individual and collective cell-migration strategies. Learning more about the cellular and molecular basis of these different migration/invasion programs will help us to understand how cancer cells disseminate and lead to new treatment strategies. Individual or collective tumor-cell migration strategies are determined by different molecular programs. From individual to collective movements, increased control of cell-ecm interaction is provided by integrins and matrix-degrading proteases.
