LIFE 102 Lecture 18: 11/03/16 Notes (Exam 3)
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It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material - watson & crick. Each parent dna strand acts as a template for base pairing to form two new daughter strands. Dna polymerase: synthesis of dna (makes a new polymer). A deoxyribonucleotide (triphosphate) is used in each addition. This is the lagging strand: the lagging strand synthesis, primase makes an rna primer, dna polymerase copies up to the 5" end of the previous primer producing. Telomeres get shorter as cells divide, and most cells in mature organism do not contain telomerase enzyme. Immortal cancer cells do have telomerase activity in about 95% of tumors. Telomerase is reactivated (when it"s not supposed to) and adds telomeres extending it life time: dolly (the cloned goat) had short telomeres, same as her dam, not a sheep her own chronological age! Is this one of the reasons that she.
