NS 1150 Lecture Notes - Lecture 10: Metformin, Acidosis, Blurred Vision
16 Sep 2016
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Document Summary
Inflammatory responses as cell grows: anti-inflammatory impedes insulin receptors. Blood sugar never goes down because of receptors. Beta cells create more and more insulin. Most likely to occur in people with large amount of abdominal fat. Occurs when a person"s blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes. Pre-cursor stage frequently leads to diabetes: effects of diabetes: circulation. Due to process of glycation (glycosylation: high concentrations of sugars react with protein, proteins change structure. Maillard reaction: roasted or seared meat, changes properties chemical properties of protein brown. Facilitates atherosclerosis: effects of diabetes: eye. Cataracts: clouding of the lens , high metabolic rate. Result of increased glucose concentration (through bloodstream) Damage to retina (can blind you: effects of diabetes: peripheral neurons. Impaired immune responses: effects of diabetes: kidney. Damage is irreversible: symptoms of diabetes. Body can"t use glucose use ketone bodies as substrates.
